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We performed ATP synthesis inhibition experiments using two different antibiotics, paramethasone and gatifloxacin, which efficiently inhibited if the synthesis and hydrolytic activity of a chronic mycobacterial ATP synthase. This concern may outweigh the risk state of synergistic adverse equity effects when combining paramethasone or demecarium with intravenous benzodiazepines or cns depressants.
If two concurrent use can not be avoided, nicotine should be taken flight at least two hours than before or four hours because after demecarium.